Product Name :
ICAM-1-IN-1
Description:
ICAM-1-IN-1 is a potent and selective inhibitor of E-selectin and ICAM-1 with IC50 values of 7 and 5 nM, respectively.
CAS:
251994-14-6
Molecular Weight:
363.23
Formula:
C15H11BrN2O2S
Chemical Name:
4-(4-bromophenoxy)-N-methylthieno[2,3-c]pyridine-2-carboxamide
Smiles :
CNC(=O)C1=CC2C(=CN=CC=2OC2C=CC(Br)=CC=2)S1
InChiKey:
OFXAEWYLVPBGGU-UHFFFAOYSA-N
InChi :
InChI=1S/C15H11BrN2O2S/c1-17-15(19)13-6-11-12(7-18-8-14(11)21-13)20-10-4-2-9(16)3-5-10/h2-8H,1H3,(H,17,19)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Nisin} site|{Nisin} Anti-infection|{Nisin} Epigenetics|{Nisin} Protocol|{Nisin} Description|{Nisin} custom synthesis}
Shelf Life:
≥12 months if stored properly.{{Seribantumab} medchemexpress|{Seribantumab} Protein Tyrosine Kinase/RTK|{Seribantumab} Biological Activity|{Seribantumab} References|{Seribantumab} manufacturer|{Seribantumab} Autophagy}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32890081
Additional information:
ICAM-1-IN-1 is a potent and selective inhibitor of E-selectin and ICAM-1 with IC50 values of 7 and 5 nM, respectively.|Product information|CAS Number: 251994-14-6|Molecular Weight: 363.23|Formula: C15H11BrN2O2S|Chemical Name: 4-(4-bromophenoxy)-N-methylthieno[2,3-c]pyridine-2-carboxamide|Smiles: CNC(=O)C1=CC2C(=CN=CC=2OC2C=CC(Br)=CC=2)S1|InChiKey: OFXAEWYLVPBGGU-UHFFFAOYSA-N|InChi: InChI=1S/C15H11BrN2O2S/c1-17-15(19)13-6-11-12(7-18-8-14(11)21-13)20-10-4-2-9(16)3-5-10/h2-8H,1H3,(H,17,19)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 135 mg/mL (371.67 mM).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|ICAM-1-IN-1 shows significant efficacy in a rat rheumatoid arthritis model and in a mouse asthma model. ICAM-1-IN-1 reduces the width of inflamed ankles after the ninth day following treatment, but shows no efficacy in the acute phase. Treatment with ICAM-1-IN-1 (25 mg/kg) for 21 days significantly reduces the ankle inflammation of the arthritis rats. Significant reduction of eosinophils and serum-soluble ICAM-1 (sICAM-1) is observed.|Products are for research use only. Not for human use.|