Product Name :
Camptothecin-20(S)-O-propionate
Description:
Camptothecin-20(S)-O-propionate (CZ48), the C20-propionate ester of CPT, is a highly effective anticancer agent. Camptothecin-20(S)-O-propionate (CZ48) is a topoisomerase-Ι inhibitor.
CAS:
194414-69-2
Molecular Weight:
404.42
Formula:
C23H20N2O5
Chemical Name:
(19S)-19-ethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0²,¹¹.0⁴,⁹.0¹⁵,²⁰]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-19-yl propanoate
Smiles :
CC[C@]1(OC(=O)CC)C2C=C3C4=NC5=CC=CC=C5C=C4CN3C(=O)C=2COC1=O
InChiKey:
YCNIQYLWIPCLNY-QHCPKHFHSA-N
InChi :
InChI=1S/C23H20N2O5/c1-3-19(26)30-23(4-2)16-10-18-20-14(9-13-7-5-6-8-17(13)24-20)11-25(18)21(27)15(16)12-29-22(23)28/h5-10H,3-4,11-12H2,1-2H3/t23-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Camptothecin-20(S)-O-propionate (CZ48), the C20-propionate ester of CPT, is a highly effective anticancer agent.{{NPPB} web|{NPPB} Chloride Channel|{NPPB} Purity & Documentation|{NPPB} In Vivo|{NPPB} supplier|{NPPB} Autophagy} Camptothecin-20(S)-O-propionate (CZ48) is a topoisomerase-Ι inhibitor.{{Belinostat} site|{Belinostat} Autophagy|{Belinostat} Biological Activity|{Belinostat} In Vivo|{Belinostat} custom synthesis|{Belinostat} Cancer} |Product information|CAS Number: 194414-69-2|Molecular Weight: 404.PMID:31643506 42|Formula: C23H20N2O5|Chemical Name: (19S)-19-ethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0²,¹¹.0⁴,⁹.0¹⁵,²⁰]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-19-yl propanoate|Smiles: CC[C@]1(OC(=O)CC)C2C=C3C4=NC5=CC=CC=C5C=C4CN3C(=O)C=2COC1=O|InChiKey: YCNIQYLWIPCLNY-QHCPKHFHSA-N|InChi: InChI=1S/C23H20N2O5/c1-3-19(26)30-23(4-2)16-10-18-20-14(9-13-7-5-6-8-17(13)24-20)11-25(18)21(27)15(16)12-29-22(23)28/h5-10H,3-4,11-12H2,1-2H3/t23-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 9.09 mg/mL (22.48 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|Camptothecin-20(S)-O-propionate (CZ48, gavage, 100 to 2000 mg/kg/day) exhibits anti-tumor activity in CLO-breast carcinoma (100 mg/kg) and PC3-prostate carcinoma (1000 mg/kg) models in mice.|Products are for research use only. Not for human use.|