uce this modify and represent a potent activator of EC. Background: Venous thromboembolism (VTE) and superficial thrombophlebitis (STP) have extended been related with cancer. Investigation of sufferers with VTE or STP may possibly let early EP Activator Purity & Documentation diagnosis of an occult malignancy, even so the benefit of substantial screening remains controversial. The Registro Informatizado de Pacientes con Enfermedad TromboEmb ica (RIETE) score aims to recognize patients D. McBriar1; B. Jacob2; G. BensonPB1109|The RIETE Score: A Valuable Screening Tool for Occult Malignancy in VTE and STPBelfast City Hospital, Belfast, United kingdom; 2NHS Fife, Edinburgh,United KingdomABSTRACT819 of|at greater threat of occult malignancy. It is actually calculated using only patient info plus a complete blood count. Aims: To evaluate the efficacy of the RIETE score at identifying occult malignancy in patents diagnosed with VTE or STP. Methods: We analyzed all sufferers managed by way of our outpatient VTE service in 2019. At present patients are reviewed in clinic, in addition to a panel of bloods including tumor markers and also a myeloma screen. The RIETE score was retrospectively applied and we followed sufferers for any minimum of a single year to ascertain if they had been subsequently diagnosed having a malignancy. Benefits: After exclusions, 390 individuals had been incorporated inside the study, of which 28 (7 ) have been identified as possessing a malignancy during this time. The RIETE score was applied employing a cut off score of 3 or higher. This returned a sensitivity for cancer of 0.54 (95 self-confidence interval 0.34.72), a positive predictive worth of 0.17 (0.12.27) plus a adverse predictive value was 0.96 (0.93.98). Hunting especially at individuals with PE the optimistic predictive value was 0.23 (0.050.54), with DVT 0.18 (0.09.31) and with STP 0.11 (0.02.29). Conclusions: This retrospective analysis demonstrates acceptable good and negative predictive values for individuals with PE, DVT and STP. Wider use could help the diagnosis of occult malignancy in these individuals, at the same time as reducing unnecessary investigation and consequent patient anxiousness. Following this study, we are going to make use of the RIETE score to discriminate which sufferers undergo additional investigation. FIGURE 2 Bar chart to show the proportion of patients at every RIETE score who went on to be diagnosed with malignancyPB1110|Differential Associations of Aromatase Inhibitors and Tamoxifen with Thrombin Generation and Sensitivity to Thrombomodulin: A Prospective Cohort Study M. Blondon; L. Thouvenin; T. Lecompte; M. Righini; P. Fontana; A. Bodmer; A. Casini Geneva University Hospitals, Geneva, Switzerland Background: Endocrine treatment options with aromatase inhibitors (AI) or tamoxifen cut down the mortality of estrogen-positive breast canFIGURE 1 Bar chart to show the distribution of sufferers by RIETE score and also the outcome of cancer screening cer. Whilst tamoxifen increases the danger of venous thromboembolism (VTE), irrespective of whether AI influence hemostasis as well as the risk of VTE remains unclear. This details is critical when assessing women with breast cancer at higher threat of VTE. Aims: Amongst women with breast cancer, to evaluate the associations of AI or tamoxifen with changes on thrombin generation and sensitivity to thrombomodulin (TM). Methods: We included 107 women with localized breast cancer, four weeks immediately after breast surgery. Exclusion criteria have been a planned CCR9 Antagonist MedChemExpress chemotherapy, a individual history of VTE in addition to a current use of exogenous hormones. We measured the laboratory hemostatic profile ahead of and 106