Tions. Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in elevated platelet production. In addition promotes the proliferation of hepatocytes in response to liver damage. Cytokine using a wide variety of biological functions in immunity, (Z)-Semaxanib supplier tissue regeneration, and metabolism. Potent inducer on the acute phase response. Chemokine that binds the receptor CCR2 and induces the chemoattraction of mononuclear cells. Induces the activation of monocytes, NK cells, lymphocytes, and basophils. Chemokine with a major part inside the inflammatory immune response by way of its ability to chemoattract leukocytes and modulate their function. CXC chemokine with pro-inflammatory effects, involved in angiogenesis. Pleiotropic cytokine. Induces the hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, as well as the stimulation of acute-phase protein synthesis in hepatocytes. Member on the leukemia inhibitory factor/oncostatin-M loved ones of proteins. Regulates cytokine production. 1.6 2.07 FC Day 7 Z/C 0.55 FC Day 21 Z/C 0.LeptinLEPResistin Serpin ARETN SERPINA1.55 0.0.81 11.VisfatinNAMPT0.0.MIF TNF BAFF/BLyS/TNFSF13B1.29 0.58 0.0.8 0.13 0.Interleukin 1 BetaIL-1B0.1.InterleukinIL-0.0.InterleukinIL-0.1.Interleukin 6 C-C Motif Chemokine Ligand 2 C-C Motif Chemokine Ligand 5 C-X-C Motif Chemokine Ligand eight Leukemia Inhibitory Issue Interleukin 6 Loved ones Cytokine Oncostatin MIL-0.1.CCL2/MCP-0.0.CCL5/RANTES1.1.CXCL8/IL-0.0.LIF0.0.OSM0.0.Toxins 2021, 13,7 ofTable 1. Cont. Protein Name Symbol Description Inflammation-related proteins Member of your pentraxin household of proteins. Sensor and activator from the innate immune response. The level of this protein in plasma increases significantly during acute phase response to tissue injury, infection, or other inflammatory stimuli. Calcium-, zinc-, and copper-binding protein having a part inside the regulation of inflammatory processes and immune response. Iron-trafficking protein involved in several processes such as apoptosis, innate immunity, and renal development. Transports modest hydrophobic molecules such as lipids, steroid hormones, and retinoids. Heme protein, part in the host defense method of polymorphonuclear leukocytes. Member of the pentraxin family members of proteins. Acts as a pattern recognition receptor with roles inside the innate immune response to various microbes. Overexpression leads to enhanced pro-inflammatory responses. Cathepsins Cathepsin D CTSD Enzyme with pepsin-like activity. Plays a function in protein turnover and inside the proteolytic activation of hormones and growth variables. Lysosomal cysteine protease. Hydrolyzes numerous proteins, which includes the proform of urokinase-type plasminogen activator. Lysosomal cysteine protease of the papain loved ones. Key protease responsible for the removal from the invariant chain from key histocompatibility complex (MHC) class II molecules and MHC class II antigen presentation. Angiopoietins Angiopoietin-1 Angiopoietin-2 AZD4625 Ras Angiopoietin-like two Angiopoietin-like 3 ANGPT1 ANGPT2 ANGPTL2 ANGPTL3 Binds the Tie-2 receptor tyrosine kinase. Critical modulator of angiogenesis. Member on the angiopoietin loved ones. Upregulated in many inflammatory diseases. Implicated within the direct manage of inflammation-related signaling pathways. Binds the Tie-2 receptor tyrosine kinase. Critical modulators of angiogenesis. Binds the Tie-2 receptor tyrosine kin.