Product Name :
GW-803430
Description:
GW-803430 (GW-3430) is a potent and selective melanin-concentrating hormone receptor 1 (MCH R1) antagonist with a pIC50 of 9.3. GW-803430 is orally active in an animal model of obesity.
CAS:
515141-51-2
Molecular Weight:
481.99
Formula:
C25H24ClN3O3S
Chemical Name:
6-(4-chlorophenyl)-3-3-methoxy-4-[2-(pyrrolidin-1-yl)ethoxy]phenyl-3H,4H-thieno[3,2-d]pyrimidin-4-one
Smiles :
COC1=CC(=CC=C1OCCN1CCCC1)N1C=NC2C=C(SC=2C1=O)C1C=CC(Cl)=CC=1
InChiKey:
MWULMTACIBZPGN-UHFFFAOYSA-N
InChi :
InChI=1S/C25H24ClN3O3S/c1-31-22-14-19(8-9-21(22)32-13-12-28-10-2-3-11-28)29-16-27-20-15-23(33-24(20)25(29)30)17-4-6-18(26)7-5-17/h4-9,14-16H,2-3,10-13H2,1H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.Bucillamine site
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.Olorofim manufacturer
Additional information:
GW-803430 (GW-3430) is a potent and selective melanin-concentrating hormone receptor 1 (MCH R1) antagonist with a pIC50 of 9.3. GW-803430 is orally active in an animal model of obesity.PMID:32470379 |Product information|CAS Number: 515141-51-2|Molecular Weight: 481.99|Formula: C25H24ClN3O3S|Chemical Name: 6-(4-chlorophenyl)-3-3-methoxy-4-[2-(pyrrolidin-1-yl)ethoxy]phenyl-3H,4H-thieno[3,2-d]pyrimidin-4-one|Smiles: COC1=CC(=CC=C1OCCN1CCCC1)N1C=NC2C=C(SC=2C1=O)C1C=CC(Cl)=CC=1|InChiKey: MWULMTACIBZPGN-UHFFFAOYSA-N|InChi: InChI=1S/C25H24ClN3O3S/c1-31-22-14-19(8-9-21(22)32-13-12-28-10-2-3-11-28)29-16-27-20-15-23(33-24(20)25(29)30)17-4-6-18(26)7-5-17/h4-9,14-16H,2-3,10-13H2,1H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|GW-803430 demonstrates a potent antagonist activity towards MCH induced MCHR1 receptor with an IC50 value of ~13 nM.|In Vivo:|GW-803430 (0.3, 3, and 15 mg/kg; oral administration; once daily) causes a sustained dose-dependent weight loss relative to vehicle controls. GW-803430 is a suitable compound for its good pharmacokinetic properties (bioavailability=31%, t1/2=11 h) and brain penetration (6:1 brain:plasma concentration) in mice.|Products are for research use only. Not for human use.|