Product Name :
Lofepramine
Description:
Lofepramine (Lopramine) is a potent tricyclic antidepressant and is extensively metabolised to Desipramine. The antidepressant activity of Lofepramine stems from the facilitation of noradrenergic neurotransmission by uptake inhibition. Lofepramine may also potentiate serotoninergic neurotransmission by inhibition of the neuronal uptake of serotonin and the enzyme tryptophan pyrrolase. Lofepramine has significant anxiolytic efficacy in addition to its antidepressant properties.
CAS:
23047-25-8
Molecular Weight:
418.96
Formula:
C26H27ClN2O
Chemical Name:
2-[(3-2-azatricyclo[9.4.0.0³,⁸]pentadeca-1(15),3,5,7,11,13-hexaen-2-ylpropyl)(methyl)amino]-1-(4-chlorophenyl)ethan-1-one
Smiles :
CN(CCCN1C2=CC=CC=C2CCC2=CC=CC=C12)CC(=O)C1C=CC(Cl)=CC=1
InChiKey:
SAPNXPWPAUFAJU-UHFFFAOYSA-N
InChi :
InChI=1S/C26H27ClN2O/c1-28(19-26(30)22-13-15-23(27)16-14-22)17-6-18-29-24-9-4-2-7-20(24)11-12-21-8-3-5-10-25(21)29/h2-5,7-10,13-16H,6,11-12,17-19H2,1H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.Farnesyl Pyrophosphate supplier
Additional information:
Lofepramine (Lopramine) is a potent tricyclic antidepressant and is extensively metabolised to Desipramine.MT1 Autophagy The antidepressant activity of Lofepramine stems from the facilitation of noradrenergic neurotransmission by uptake inhibition.PMID:32544974 Lofepramine may also potentiate serotoninergic neurotransmission by inhibition of the neuronal uptake of serotonin and the enzyme tryptophan pyrrolase. Lofepramine has significant anxiolytic efficacy in addition to its antidepressant properties.|Product information|CAS Number: 23047-25-8|Molecular Weight: 418.96|Formula: C26H27ClN2O|Chemical Name: 2-[(3-2-azatricyclo[9.4.0.0³,⁸]pentadeca-1(15),3,5,7,11,13-hexaen-2-ylpropyl)(methyl)amino]-1-(4-chlorophenyl)ethan-1-one|Smiles: CN(CCCN1C2=CC=CC=C2CCC2=CC=CC=C12)CC(=O)C1C=CC(Cl)=CC=1|InChiKey: SAPNXPWPAUFAJU-UHFFFAOYSA-N|InChi: InChI=1S/C26H27ClN2O/c1-28(19-26(30)22-13-15-23(27)16-14-22)17-6-18-29-24-9-4-2-7-20(24)11-12-21-8-3-5-10-25(21)29/h2-5,7-10,13-16H,6,11-12,17-19H2,1H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 50 mg/mL (119.34 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|