Product Name :
LY-411575 (isomer 2)
Description:
LY-411575 isomer 2, is an isomer of LY411575, which is a potent, cell-permeable γ-secretase inhibitor (IC50= 0.078 nM/0.082 nM (in membrane-assay/in cell-basedγ-secretase assays)) and also inhibits Notch clevage (IC50= 0.41 nM).
CAS:
2070009-70-8
Molecular Weight:
479.48
Formula:
C26H23F2N3O4
Chemical Name:
(2R)-2-[(2S)-2-(3, 5-difluorophenyl)-2-hydroxyacetamido]-N-[(10S)-8-methyl-9-oxo-8-azatricyclo[9.4.0.0, ]pentadeca-1(11), 2(7), 3, 5, 12, 14-hexaen-10-yl]propanamide
Smiles :
C[C@@H](NC(=O)[C@@H](O)C1=CC(F)=CC(F)=C1)C(=O)N[C@@H]1C(=O)N(C)C2=CC=CC=C2C2=CC=CC=C21
InChiKey:
ULSSJYNJIZWPSB-ILFDSTAHSA-N
InChi :
InChI=1S/C26H23F2N3O4/c1-14(29-25(34)23(32)15-11-16(27)13-17(28)12-15)24(33)30-22-20-9-4-3-7-18(20)19-8-5-6-10-21(19)31(2)26(22)35/h3-14,22-23,32H,1-2H3,(H,29,34)(H,30,33)/t14-,22+,23+/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Depatuxizumab Protocol
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
LY-411575 isomer 2, is an isomer of LY411575, which is a potent, cell-permeable γ-secretase inhibitor (IC50= 0.078 nM/0.082 nM (in membrane-assay/in cell-basedγ-secretase assays)) and also inhibits Notch clevage (IC50= 0.41 nM).|Product information|CAS Number: 2070009-70-8|Molecular Weight: 479.48|Formula: C26H23F2N3O4|Synonym:|LY411575 isomer 2|LY 411575 isomer 2|Chemical Name: (2R)-2-[(2S)-2-(3, 5-difluorophenyl)-2-hydroxyacetamido]-N-[(10S)-8-methyl-9-oxo-8-azatricyclo[9.4.0.0, ]pentadeca-1(11), 2(7), 3, 5, 12, 14-hexaen-10-yl]propanamide|Smiles: C[C@@H](NC(=O)[C@@H](O)C1=CC(F)=CC(F)=C1)C(=O)N[C@@H]1C(=O)N(C)C2=CC=CC=C2C2=CC=CC=C21|InChiKey: ULSSJYNJIZWPSB-ILFDSTAHSA-N|InChi: InChI=1S/C26H23F2N3O4/c1-14(29-25(34)23(32)15-11-16(27)13-17(28)12-15)24(33)30-22-20-9-4-3-7-18(20)19-8-5-6-10-21(19)31(2)26(22)35/h3-14,22-23,32H,1-2H3,(H,29,34)(H,30,33)/t14-,22+,23+/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Nordihydroguaiaretic acid Autophagy |Shelf Life: ≥12 months if stored properly.PMID:31711314 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Fauq AH, et al. A multigram chemical synthesis of the gamma-secretase inhibitor LY411575 and its diastereoisomers. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6392-5. Epub 2007 Aug 30.Products are for research use only. Not for human use.|