Product Name :
Quinacrine dihydrochloride

Description:
Quinacrine (Mepacrine) dihydrochloride is an orally bioavailable antimalarial agent, which possess anticancer effect both in vitro and vivo. Quinacrine dihydrochloride suppresses NF-κB and activate p53 signaling, which results in the induction of the apoptosis.

CAS:
69-05-6

Molecular Weight:
472.88

Formula:
C23H32Cl3N3O

Chemical Name:
6-chloro-N-[5-(diethylamino)pentan-2-yl]-2-methoxyacridin-9-amine dihydrochloride

Smiles :
Cl.Cl.COC1=CC2=C(NC(C)CCCN(CC)CC)C3=CC=C(Cl)C=C3N=C2C=C1

InChiKey:
UDKVBVICMUEIKS-UHFFFAOYSA-N

InChi :
InChI=1S/C23H30ClN3O.2ClH/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23;;/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26);2*1H

Purity:
≥98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life:
≥12 months if stored properly.

Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.

Additional information:
Quinacrine (Mepacrine) dihydrochloride is an orally bioavailable antimalarial agent, which possess anticancer effect both in vitro and vivo. Quinacrine dihydrochloride suppresses NF-κB and activate p53 signaling, which results in the induction of the apoptosis.|Product information|CAS Number: 69-05-6|Molecular Weight: 472.88|Formula: C23H32Cl3N3O|Synonym:|Mepacrine dihydrochloride|SN-390 dihydrochloride|Chemical Name: 6-chloro-N-[5-(diethylamino)pentan-2-yl]-2-methoxyacridin-9-amine dihydrochloride|Smiles: Cl.Cl.COC1=CC2=C(NC(C)CCCN(CC)CC)C3=CC=C(Cl)C=C3N=C2C=C1|InChiKey: UDKVBVICMUEIKS-UHFFFAOYSA-N|InChi: InChI=1S/C23H30ClN3O.2ClH/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23;;/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26);2*1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 44 mg/mL (93.05 mM) H2O : 13.89 mg/mL (29.37 mM; Need ultrasonic)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Quinacrine (5-20 μM; 24 hours) inhibits the growth of SGC-7901 cells. Quinacrine (7.5 and 15 μM; 24 hours) induces apoptosis in SGC-7901 cells, which is associated with mitochondria-dependent signal pathway and involves p53 upregulation and caspase-3 activation pathway.{{IL-2 Protein, Human} web|{IL-2 Protein, Human} Biological Activity|{IL-2 Protein, Human} In Vivo|{IL-2 Protein, Human} supplier|{IL-2 Protein, Human} Epigenetic Reader Domain} Quinacrine (15 μM; 24 hours) treatment significantly increased the levels of proapoptotic proteins, including cytochrome c, Bax, and p53, and decreased the levels of antiapoptotic protein Bcl-2, thus shifting the ratio of Bax/Bcl-2 in favor of apoptosis.{{Bosentan} web|{Bosentan} Endothelin Receptor|{Bosentan} Protocol|{Bosentan} Purity|{Bosentan} supplier|{Bosentan} Autophagy} |In Vivo:|Quinacrine (100 mg/kg three times per week for two consecutive weeks) significantly suppresses circulating blast cells at days 30/31 and increases the median survival time (MST).PMID:33300759 Quinacrine does not decrease the body weight of treated animals at the tested dose.|References:|Xiaoyang Wu, et al. Quinacrine Inhibits Cell Growth and Induces Apoptosis in Human Gastric Cancer Cell Line SGC-7901. Curr Ther Res Clin Exp. 2012 Feb;73(1-2):52-64.Anna Eriksson, et al. Towards repositioning of quinacrine for treatment of acute myeloid leukemia – Promising synergies and in vivo effects. Leuk Res. 2017 Dec;63:41-46.Products are for research use only. Not for human use.|

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