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p53 monoclonal antibody (PAb122)
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p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to Mdm2, SV40 T antigen and human Papilloma virus E6 protein. p53 senses DNA damage and facilitates its repair. Mutation involving p53 is found in a wide variety of malignant tumors, including breast, ovary, bladder, colon, lung, and melanoma. Western blot analysis of p53: Lane 1: MW marker, Lane 2: A431, Lane 3: rat brain, Lane 4: mouse brain.{{437982-89-3} medchemexpress|{437982-89-3} Purity & Documentation|{437982-89-3} In stock|{437982-89-3} custom synthesis} Endometrial carcinoma stained by immunohistochemistry with p53 monoclonal antibody (PAb122) (ENZ-ABS849, 1:20 Dilution). Endometrial carcinoma stained by immunohistochemistry with p53 monoclonal antibody (PAb122) (ENZ-ABS849, 1:20 Dilution). Flow cytometry analysis of 10^6 Jurkat cells stained using p53 monoclonal antibody (PAb122), , at a concentration of 50 µg/mL.{{1820563-84-5} web|{1820563-84-5} Purity & Documentation|{1820563-84-5} Data Sheet|{1820563-84-5} supplier} Western blot analysis of p53: Lane 1: MW marker, Lane 2: A431, Lane 3: rat brain, Lane 4: mouse brain. Endometrial carcinoma stained by immunohistochemistry with p53 monoclonal antibody (PAb122) (ENZ-ABS849, 1:20 Dilution). Endometrial carcinoma stained by immunohistochemistry with p53 monoclonal antibody (PAb122) (ENZ-ABS849, 1:20 Dilution). Flow cytometry analysis of 10^6 Jurkat cells stained using p53 monoclonal antibody (PAb122), , at a concentration of 50 µg/mL.
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| Alternative Name TRP53, Tumor protein p53 | Application Flow Cytometry, ICC, IHC, IP, WB | Application Notes Detects a band of ~48/53kDa by Western blot.PMID:25905200 | Clone pAb122 | Crossreactivity Weakly cross-reacts with dog p53. | Formulation Liquid. In PBS containing 50% glycerol and 0.09% sodium azide. | Host Mouse | Immunogen SV40 transformed 3T3 cells. | Isotype IgG2b | Recommendation Dilutions/Conditions Western Blot (1:250 colorimetric, 1:250 ECL)Immunohistochemistry (1:20 – 1:100)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application. | Source Purified from hybridoma tissue culture supernatant. | Species Reactivity Human, Mouse, Rat | UniProt ID P02340 | Unit of Measure (UM) mg, µg