Product Name :
SAR629
Description:
SAR629 is a potent monoglyceride lipase (MGL) covalent inhibitor. SAR629 also inhibits 2-Arachidonoylglycerol (2-AG) degradation.
CAS:
1221418-42-3
Molecular Weight:
383.39
Formula:
C20H19F2N5O
Chemical Name:
1-[bis(4-fluorophenyl)methyl]-4-(1H-1,2,4-triazole-1-carbonyl)piperazine
Smiles :
O=C(N1C=NC=N1)N1CCN(CC1)C(C1C=CC(F)=CC=1)C1C=CC(F)=CC=1
InChiKey:
UIOVHJYJUUSVIG-UHFFFAOYSA-N
InChi :
InChI=1S/C20H19F2N5O/c21-17-5-1-15(2-6-17)19(16-3-7-18(22)8-4-16)25-9-11-26(12-10-25)20(28)27-14-23-13-24-27/h1-8,13-14,19H,9-12H2
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
SAR629 is a potent monoglyceride lipase (MGL) covalent inhibitor. SAR629 also inhibits 2-Arachidonoylglycerol (2-AG) degradation.|Product information|CAS Number: 1221418-42-3|Molecular Weight: 383.39|Formula: C20H19F2N5O|Chemical Name: 1-[bis(4-fluorophenyl)methyl]-4-(1H-1,2,4-triazole-1-carbonyl)piperazine|Smiles: O=C(N1C=NC=N1)N1CCN(CC1)C(C1C=CC(F)=CC=1)C1C=CC(F)=CC=1|InChiKey: UIOVHJYJUUSVIG-UHFFFAOYSA-N|InChi: InChI=1S/C20H19F2N5O/c21-17-5-1-15(2-6-17)19(16-3-7-18(22)8-4-16)25-9-11-26(12-10-25)20(28)27-14-23-13-24-27/h1-8,13-14,19H,9-12H2|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Malonyl CoA} medchemexpress|{Malonyl CoA} Mitochondrial Metabolism|{Malonyl CoA} Activator|{Malonyl CoA} Protocol|{Malonyl CoA} In Vivo|{Malonyl CoA} custom synthesis} |Shelf Life: ≥12 months if stored properly.{{Isocarboxazid} medchemexpress|{Isocarboxazid} Neuronal Signaling|{Isocarboxazid} Biological Activity|{Isocarboxazid} Purity|{Isocarboxazid} custom synthesis|{Isocarboxazid} Epigenetic Reader Domain} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:36717102 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|SAR629 is a potent dual inhibitory action on MAGL and fatty acid amide hydrolase (FAAH). SAR629 inhibits rodent monoglyceride lipase (MGL) activity at subnanomolar potencies (IC50 values of 1.1 nM and 219 pM in rat and mouse brain membranes, respectively).|Products are for research use only. Not for human use.|