Product Name :
Nemifitide diTFA
Description:
Nemifitide diTFA (INN 00835 diTFA) is a synthetic pentapeptide antidepressant with a potential for rapid onset of action. Nemifitide diTFA is a peptide analog of melanocyte-inhibiting factor (MIF). Nemifitide diTFA can cross the blood-brain barrier.
CAS:
204992-09-6
Molecular Weight:
922.80
Formula:
C37H45F7N10O10
Chemical Name:
(2S)-2-{[(2S,4R)-1-[(2S)-2-amino-3-(4-fluorophenyl)propanoyl]-4-hydroxypyrrolidin-2-yl]formamido}-N-({[(1S)-1-carbamoyl-2-(1H-indol-3-yl)ethyl]carbamoyl}methyl)-5-[(diaminomethylidene)amino]pentanamide; bis(trifluoroacetic acid)
Smiles :
NC(N)=NCCC[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](N)CC1C=CC(F)=CC=1)C(=O)NCC(=O)N[C@@H](CC1=CNC2=CC=CC=C12)C(N)=O.OC(=O)C(F)(F)F.OC(=O)C(F)(F)F
InChiKey:
QXCFOJXOLMOPRK-QOXNQHIRSA-N
InChi :
InChI=1S/C33H43FN10O6.2C2HF3O2/c34-20-9-7-18(8-10-20)12-23(35)32(50)44-17-21(45)14-27(44)31(49)43-25(6-3-11-39-33(37)38)30(48)41-16-28(46)42-26(29(36)47)13-19-15-40-24-5-2-1-4-22(19)24;2*3-2(4,5)1(6)7/h1-2,4-5,7-10,15,21,23,25-27,40,45H,3,6,11-14,16-17,35H2,(H2,36,47)(H,41,48)(H,42,46)(H,43,49)(H4,37,38,39);2*(H,6,7)/t21-,23+,25+,26+,27+;;/m1../s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Hypromellose} web|{Hypromellose} Protocol|{Hypromellose} Formula|{Hypromellose} custom synthesis|{Hypromellose} Cancer}
Shelf Life:
≥12 months if stored properly.{{Cyclophosphamide} web|{Cyclophosphamide} Cell Cycle/DNA Damage|{Cyclophosphamide} Biological Activity|{Cyclophosphamide} Purity|{Cyclophosphamide} supplier|{Cyclophosphamide} Epigenetic Reader Domain}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23912708
Additional information:
Nemifitide diTFA (INN 00835 diTFA) is a synthetic pentapeptide antidepressant with a potential for rapid onset of action. Nemifitide diTFA is a peptide analog of melanocyte-inhibiting factor (MIF). Nemifitide diTFA can cross the blood-brain barrier.|Product information|CAS Number: 204992-09-6|Molecular Weight: 922.80|Formula: C37H45F7N10O10|Chemical Name: (2S)-2-{[(2S,4R)-1-[(2S)-2-amino-3-(4-fluorophenyl)propanoyl]-4-hydroxypyrrolidin-2-yl]formamido}-N-({[(1S)-1-carbamoyl-2-(1H-indol-3-yl)ethyl]carbamoyl}methyl)-5-[(diaminomethylidene)amino]pentanamide; bis(trifluoroacetic acid)|Smiles: NC(N)=NCCC[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](N)CC1C=CC(F)=CC=1)C(=O)NCC(=O)N[C@@H](CC1=CNC2=CC=CC=C12)C(N)=O.OC(=O)C(F)(F)F.OC(=O)C(F)(F)F|InChiKey: QXCFOJXOLMOPRK-QOXNQHIRSA-N|InChi: InChI=1S/C33H43FN10O6.2C2HF3O2/c34-20-9-7-18(8-10-20)12-23(35)32(50)44-17-21(45)14-27(44)31(49)43-25(6-3-11-39-33(37)38)30(48)41-16-28(46)42-26(29(36)47)13-19-15-40-24-5-2-1-4-22(19)24;2*3-2(4,5)1(6)7/h1-2,4-5,7-10,15,21,23,25-27,40,45H,3,6,11-14,16-17,35H2,(H2,36,47)(H,41,48)(H,42,46)(H,43,49)(H4,37,38,39);2*(H,6,7)/t21-,23+,25+,26+,27+;;/m1../s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: H2O : 250 mg/mL (270.91 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Nemifitide diTFA (INN 00835 diTFA) and its active metabolite (M1) bind at micromolar concentrations to several receptors including the 5-HT2A, 5-HT2C, melanocortin MC4, MC5 and bombesin.|In Vivo:|Nemifitide diTFA (INN 00835 diTFA; 0.3 mg/kg; IP; daily; for 14 days) significantly increases swimming in the FSL rats after just 5 days of treatment and has long-lasting effect. Nemifitide diTFA (0.0125-15.0 mg/kg) significantly increases swimming in the FSL rats at both low (0.025-0.3 mg/kg) and high (3.0-15.0 mg/kg) doses but not at intermediate (0.4-2.4 mg/kg) doses.|Products are for research use only. Not for human use.|