Product Name :
H-Cys(Trt)-OH
Description:
H-Cys(Trt)-OH (L-Cys(Trt)-OH, H-L-Cys(Trt)-OH, S-Tritylcysteine) is a specific inhibitor of Eg5 that inhibits Eg5-driven microtubule sliding velocity in a reversible fashion with an IC50 of 500 nM.
CAS:
2799-07-7
Molecular Weight:
363.47
Formula:
C22H21NO2S
Chemical Name:
2-amino-3-[(triphenylmethyl)sulfanyl]propanoic acid
Smiles :
NC(CSC(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)C(O)=O
InChiKey:
DLMYFMLKORXJPO-UHFFFAOYSA-N
InChi :
InChI=1S/C22H21NO2S/c23-20(21(24)25)16-26-22(17-10-4-1-5-11-17,18-12-6-2-7-13-18)19-14-8-3-9-15-19/h1-15,20H,16,23H2,(H,24,25)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.{{Dapagliflozin} medchemexpress|{Dapagliflozin} SGLT|{Dapagliflozin} Purity & Documentation|{Dapagliflozin} Description|{Dapagliflozin} manufacturer|{Dapagliflozin} Autophagy}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
H-Cys(Trt)-OH (L-Cys(Trt)-OH, H-L-Cys(Trt)-OH, S-Tritylcysteine) is a specific inhibitor of Eg5 that inhibits Eg5-driven microtubule sliding velocity in a reversible fashion with an IC50 of 500 nM.|Product information|CAS Number: 2799-07-7|Molecular Weight: 363.47|Formula: C22H21NO2S|Chemical Name: 2-amino-3-[(triphenylmethyl)sulfanyl]propanoic acid|Smiles: NC(CSC(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)C(O)=O|InChiKey: DLMYFMLKORXJPO-UHFFFAOYSA-N|InChi: InChI=1S/C22H21NO2S/c23-20(21(24)25)16-26-22(17-10-4-1-5-11-17,18-12-6-2-7-13-18)19-14-8-3-9-15-19/h1-15,20H,16,23H2,(H,24,25)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Solubility (25°C). 5 mg/mL(13.75 mM).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|In cell-based assays, H-Cys(Trt)-OH (S-trityl-l-cysteine) does not prevent cell cycle progression at the S or G2 phases but inhibits both separation of the duplicated centrosomes and bipolar spindle formation, thereby blocking cells specifically in the M phase of the cell cycle with monoastral spindles.{{Fosamprenavir} MedChemExpress|{Fosamprenavir} Endogenous Metabolite|{Fosamprenavir} Purity & Documentation|{Fosamprenavir} Formula|{Fosamprenavir} custom synthesis|{Fosamprenavir} Cancer} Following removal of S-trityl-l-cysteine, mitotically arrested cells exit mitosis normally.PMID:23935843 In vitro, S-trityl-l-cysteine targets the catalytic domain of Eg5 and inhibits Eg5 basal and microtubule-activated ATPase activity as well as mant-ADP release. It is a tight binding inhibitor and inhibits Eg5-driven microtubule sliding velocity in a reversible fashion with an IC50 of 500 nM.|Products are for research use only. Not for human use.|