Product Name :
Palifosfamide
Description:
Palifosfamide, also known as ZIO201, is a synthetic mustard compound with potential antineoplastic activity. An active metabolite of ifosfamide covalently linked to the amino acid lysine for stability, palifosfamide irreversibly alkylates and cross-links DNA through GC base pairs, resulting in irreparable 7-atom inter-strand cross-links; inhibition of DNA replication and cell death follow. Unlike ifosfamide, this agent is not metabolized to acrolein or chloroacetaldehyde, metabolites associated with bladder and CNS toxicities. In addition, because palifosfamide does not require activation by aldehyde dehydrogenase, it may overcome the tumor resistance seen with ifosfamide.
CAS:
31645-39-3
Molecular Weight:
221.02
Formula:
C4H11Cl2N2O2P
Chemical Name:
bis[(2-chloroethyl)amino]phosphinic acid
Smiles :
OP(=O)(NCCCl)NCCCl
InChiKey:
BKCJZNIZRWYHBN-UHFFFAOYSA-N
InChi :
InChI=1S/C4H11Cl2N2O2P/c5-1-3-7-11(9,10)8-4-2-6/h1-4H2,(H3,7,8,9,10)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Valrubicin} MedChemExpress|{Valrubicin} PKC|{Valrubicin} Purity & Documentation|{Valrubicin} Formula|{Valrubicin} custom synthesis|{Valrubicin} Epigenetics}
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Palifosfamide, also known as ZIO201, is a synthetic mustard compound with potential antineoplastic activity. An active metabolite of ifosfamide covalently linked to the amino acid lysine for stability, palifosfamide irreversibly alkylates and cross-links DNA through GC base pairs, resulting in irreparable 7-atom inter-strand cross-links; inhibition of DNA replication and cell death follow. Unlike ifosfamide, this agent is not metabolized to acrolein or chloroacetaldehyde, metabolites associated with bladder and CNS toxicities.{{Tedizolid} MedChemExpress|{Tedizolid} Anti-infection|{Tedizolid} Protocol|{Tedizolid} Purity|{Tedizolid} manufacturer|{Tedizolid} Cancer} In addition, because palifosfamide does not require activation by aldehyde dehydrogenase, it may overcome the tumor resistance seen with ifosfamide.PMID:24013184 |Product information|CAS Number: 31645-39-3|Molecular Weight: 221.02|Formula: C4H11Cl2N2O2P|Chemical Name: bis[(2-chloroethyl)amino]phosphinic acid|Smiles: OP(=O)(NCCCl)NCCCl|InChiKey: BKCJZNIZRWYHBN-UHFFFAOYSA-N|InChi: InChI=1S/C4H11Cl2N2O2P/c5-1-3-7-11(9,10)8-4-2-6/h1-4H2,(H3,7,8,9,10)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|