Fig 3A and 3B show that hydrogen peroxide enhances the phosphorylation (activation) of Src in SK-BR-3 cells, and that the CaM antagonist W-7 inhibits the hydrogen peroxide-dependent activation
Moreover, hydrogen peroxide strongly activated the EGFR, a method that was inhibited by the Src inhibitor PP1 (not shown), BI-7273 suggesting that this was a consequence of EGFR phosphorylation by…