A schematic model summarizes the complex cell signaling in the circadian regulation of L-VGCCs. The circadian clock in the photoreceptor regulates the mRNA levels and protein expression of the channel forming L-VGCC1 subunits
Additional specially, the di-phosphorylation of ERK (pERK) and phosphorylation of AKT at thr308 (pAKTthr308) are substantially better at night time than for the duration of the working day . Given…