Consequently, we also established the effect of EMEPO on b-AR stimulated contraction in NOS12/2 and WT myocytes. Revealed in Determine 4B, EMEPO incubation substantially improved b-AR stimulated Ca2+ transient amplitude in NOS12/two
P,.05 NOS12/2 +ISO vs NOS12/two +ISO/EMEPO. n = 13 cells/five hearts for NOS12/2 +ISO, n = 10 cells/4 heart for NOS12/two +ISO/EMEPO, n = 16 cells/6 hearts for WT +ISO,…