To figure out if A1AT glycosylation takes place in the endothelium, we employed SDS-Site to keep track of the motion of gradual migrating (glycosylated) and quick migrating (unglycosylated) A1AT bands immediately after A1AT remedy for 4 h

Mice were injected by means of jugular vein with A1AT (10 mg/kg) labeledVLX1570 with Alexa Fluor 488. Immediately next intravenous injection, A1AT co-localized with the TR-dextran-labeled lung microcirculation (Fig. 1).…